Urobolin is a supplement that comes from punica granatum (Pomegranate) that is standardized to Urolithin B. Urobolin as a supplement can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.
In studies, UroBolin at 15µM promoted androgen receptor activity by 90% vs. testosterone at 100µM which promoted androgen receptor activity by 50%. Even at significantly lower doses, it outperformed testosterone. Additionally, UroBolin at 15µM upregulated muscle protein synthesis by 96% while insulin at 100 µM upregulated MPS by just 61%. Once again, at a significantly lower dose, UroBolin was more effective than Insulin at increasing muscle protein synthesis.